Clitinerary® is a patient referral management system that helps the physicians to optimize the patient itinerary by recommending the best therapy indications. This platform also connects physicians not specialized in specific therapies with the experts in those treatments. It represents a measurable benefit to patients (early diagnosis and treatment optimization), physicians (support for decisions based on evidence and clinical guidelines), specialized medical centers (better flow of referred patients and connection to referring centers), public institutions (global cost analysis), and industry (identification of larger number of patients.